ABOUT THE RESEARCHER

OVERVIEW

Dr. Sung Chun studies computational and statistical genetics of rare and complex pulmonary disorders. His focus is in developing polygenic risk prediction algorithms and genetic colocalization tests to study the genetic architecture of pulmonary genetic disorders.

BACKGROUND

Dr. Sung Chun received PhD in Computational and Systems Biology at Washington University in St. Louis in 2012. He did postdoctoral training in Genetics in Dr. Shamil Sunyaev's laboratory, Brigham and Women's Hospital/Harvard Medical School. He has been an Instructor at Harvard Medical School since 2015. In 2019 he joined the Division of Pulmonary Medicine at BCH.

Selected Publications

  1. Chun and Imakaev et al. (2018) Non-parametric polygenic risk prediction using partitioned GWAS summary statistics. (preprint).
  2. Chun et al. (2017) Limited statistical evidence for shared genetic effects of eQTLs and autoimmune disease-associated loci in three major immune cell types. Nat Genet. 2017 Apr; 49(4): 600–605.
  3. Savova, Chun and Sohail et al. (2016) Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat Genet. 2016 Mar; 48(3): 231–237.
  4. Chun and Fay. (2011) Evidence for Hitchhiking of Deleterious Mutations within the Human Genome. PLoS Genet. 2011 Aug; 7(8): e1002240.
  5. Chun and Fay. (2009) Identification of deleterious mutations within three human genomes. Genome Res. 2009 Sep; 19(9): 1553–1561.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Chun S, Imakaev M, Hui D, Patsopoulos NA, Neale BM, Kathiresan S, Stitziel NO, Sunyaev SR. Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics. Am J Hum Genet. 2020 Jul 02; 107(1):46-59. View abstract
  2. Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, Frazier-Wood AC, Gharib SA, Haba-Rubio J, Hagen EW, Heinzer R, Hillman DR, Johnson WC, Kutalik Z, Lane JM, Larkin EK, Lee SK, Liang J, Loredo JS, Mukherjee S, Palmer LJ, Papanicolaou GJ, Penzel T, Peppard PE, Post WS, Ramos AR, Rice K, Rotter JI, Sands SA, Shah NA, Shin C, Stone KL, Stubbe B, Sul JH, Tafti M, Taylor KD, Teumer A, Thornton TA, Tranah GJ, Wang C, Wang H, Warby SC, Wellman DA, Zee PC, Hanis CL, Laurie CC, Gottlieb DJ, Patel SR, Zhu X, Sunyaev SR, Saxena R, Lin X, Redline S. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018 03; 58(3):391-401. View abstract
  3. Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet. 2017 Apr; 49(4):600-605. View abstract
  4. Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S. Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):886-897. View abstract
  5. Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat Genet. 2016 Mar; 48(3):231-237. View abstract
  6. Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D. An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood. Rheumatology (Oxford). 2016 Mar; 55(3):586-9. View abstract
  7. Akle S, Chun S, Jordan DM, Cassa CA. Mitigating false-positive associations in rare disease gene discovery. Hum Mutat. 2015 Oct; 36(10):998-1003. View abstract
  8. Nikolskiy I, Conrad DF, Chun S, Fay JC, Cheverud JM, Lawson HA. Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides. BMC Genomics. 2015 May 28; 16:415. View abstract
  9. Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, Arndt PF, Kloosterman WP, de Bakker PIW, Sunyaev SR. Genome-wide patterns and properties of de novo mutations in humans. Nat Genet. 2015 Jul; 47(7):822-826. View abstract
  10. Yim HS, Cho YS, Guang X, Kang SG, Jeong JY, Cha SS, Oh HM, Lee JH, Yang EC, Kwon KK, Kim YJ, Kim TW, Kim W, Jeon JH, Kim SJ, Choi DH, Jho S, Kim HM, Ko J, Kim H, Shin YA, Jung HJ, Zheng Y, Wang Z, Chen Y, Chen M, Jiang A, Li E, Zhang S, Hou H, Kim TH, Yu L, Liu S, Ahn K, Cooper J, Park SG, Hong CP, Jin W, Kim HS, Park C, Lee K, Chun S, Morin PA, O'Brien SJ, Lee H, Kimura J, Moon DY, Manica A, Edwards J, Kim BC, Kim S, Wang J, Bhak J, Lee HS, Lee JH. Minke whale genome and aquatic adaptation in cetaceans. Nat Genet. 2014 Jan; 46(1):88-92. View abstract
  11. Chun S, Plunkett J, Teramo K, Muglia LJ, Fay JC. Fine-mapping an association of FSHR with preterm birth in a Finnish population. PLoS One. 2013; 8(10):e78032. View abstract
  12. Chun S, Fay JC. Evidence for hitchhiking of deleterious mutations within the human genome. PLoS Genet. 2011 Aug; 7(8):e1002240. View abstract
  13. Chun S, Fay JC. Identification of deleterious mutations within three human genomes. Genome Res. 2009 Sep; 19(9):1553-61. View abstract
  14. Seo DD, Lee HC, Kim HJ, Min HJ, Kim KM, Lim YS, Chung YH, Lee YS, Suh DJ, Yu E, Chun SY. Neural cadherin overexpression is a predictive marker for early postoperative recurrence in hepatocellular carcinoma patients. J Gastroenterol Hepatol. 2008 Jul; 23(7 Pt 1):1112-8. View abstract