Transplant Research Program

At Boston Children's Hospital, our ultimate goal is to optimize success and improve outcomes following solid organ transplantation. This goal is achieved through the use of innovative new research tools and techniques, and new immunosuppressive medications that preserve organ function while allowing children to grow and develop as healthy adolescents and adults following transplantation.

To maximize our potential to accelerate discovery and ultimately to improve care, the Department of Medicine at Boston Children's launched a Transplant Research Program, directed by Dr. David Briscoe. The focus of the program is to perform basic research to further understand the molecular basis for chronic allograft rejection in children, which is the leading cause of graft failure following transplantation. Members of the Transplant Research Program also study the alloimmune response, the cellular basis for immunomodulation, and roles for new molecules, novel receptors, and signaling pathways that are causative of disease after transplantation. The application of these discoveries clinically advance our understanding of alloimmunity, our approach to therapy, and have high potential to limit complications following transplantation. Our overall goal is to transform clinical care through basic and translational research and discovery.

To learn about the research each of faculty within the program are doing, see our Faculty Research page.