ABOUT THE RESEARCHER

OVERVIEW

Dr. Sharma’s research focuses on metabolic complications related to antiretroviral medications in children and adolescents with HIV infection.  As children who were perinatally-infected with HIV are getting older and remaining healthier since they have been receiving anti-HIV therapy for many years, we are now beginning to see changes in body composition, an increased risk of diabetes, and increasing risk of other cardiovascular complications in these children.  Dr. Sharma’s research entails evaluating the mechanisms by which these abnormalities occur, and whether life-saving antiretroviral medications may also contribute to some of these complications.  In addition, Dr. Sharma conducts research evaluating infectious complications such as viral infections in pediatric transplant recipients.

BACKGROUND

Dr. Sharma received her medical degree from the University of Miami Miller School of Medicine. She completed her residency training in pediatrics and fellowship in pediatric infectious diseases and immunology at the University of Miami/Jackson Memorial Medical Center in Miami, Florida.  Dr. Sharma joined the faculty in the Division of Infectious Diseases at Children’s Hospital Boston in 2007.  She currently serves as the Program Director for the pediatric infectious diseases fellowship.

PUBLICATIONS

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  1. H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model. Cancer Cell. 2021 Jan 29. View abstract
  2. Return to School for Pediatric Solid Organ Transplant Recipients in the United States During the Coronavirus Disease 2019 Pandemic: Expert Opinion on Key Considerations and Best Practices. J Pediatric Infect Dis Soc. 2020 Nov 10; 9(5):551-563. View abstract
  3. Expanding the Differential in a Global Pandemic. Pediatr Infect Dis J. 2020 10; 39(10):e334-e335. View abstract
  4. Limiting Vancomycin Exposure in Pediatric Oncology Patients With Febrile Neutropenia May Be Associated With Decreased Vancomycin-Resistant Enterococcus Incidence. J Pediatric Infect Dis Soc. 2020 Sep 17; 9(4):428-436. View abstract
  5. Mitochondrial Dysfunction and Insulin Resistance in Pubertal Youth Living with Perinatally Acquired HIV. AIDS Res Hum Retroviruses. 2020 09; 36(9):703-711. View abstract
  6. Assessment of the Clinical Utility of Plasma Metagenomic Next-Generation Sequencing in a Pediatric Hospital Population. J Clin Microbiol. 2020 06 24; 58(7). View abstract
  7. Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient. Transpl Infect Dis. 2020 Aug; 22(4):e13304. View abstract
  8. A Primary Care-Based Quality Improvement Initiative to Increase Identification of Pediatric International Travelers. Am J Trop Med Hyg. 2020 05; 102(5):1016-1021. View abstract
  9. Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort. J Clin Oncol. 2020 06 20; 38(18):2028-2040. View abstract
  10. Advances in vaccinating immunocompromised children. Curr Opin Pediatr. 2020 02; 32(1):145-150. View abstract
  11. Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma. J Clin Oncol. 2020 01 01; 38(1):43-50. View abstract
  12. Impact of standardized protocols for cytomegalovirus disease prevention in pediatric solid organ transplant recipients. Pediatr Transplant. 2019 11; 23(7):e13568. View abstract
  13. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun. 2019 09 02; 10(1):3914. View abstract
  14. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79. View abstract
  15. Human T-cell lymphotrophic virus in solid-organ transplant recipients: Guidelines from the American society of transplantation infectious diseases community of practice. Clin Transplant. 2019 09; 33(9):e13575. View abstract
  16. Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes. Acta Neuropathol. 2019 08; 138(2):309-326. View abstract
  17. Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8. Pediatr Transplant. 2019 05; 23(3):e13384. View abstract
  18. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  19. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  20. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  21. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  22. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  23. A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients. Clin Infect Dis. 2018 10 15; 67(9):1322-1329. View abstract
  24. Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth. Pediatr Infect Dis J. 2018 10; 37(10):1002-1007. View abstract
  25. Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell. 2018 09 10; 34(3):379-395.e7. View abstract
  26. Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol. 2018 08; 136(2):227-237. View abstract
  27. Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. Lancet Oncol. 2018 06; 19(6):768-784. View abstract
  28. Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents. AIDS. 2018 03 13; 32(5):613-622. View abstract
  29. Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis. Brain Pathol. 2018 09; 28(5):656-662. View abstract
  30. DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma. Acta Neuropathol. 2017 Dec; 134(6):965-967. View abstract
  31. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 2017 Sep; 134(3):507-516. View abstract
  32. A Prospective, International Cohort Study of Invasive Mold Infections in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):313-22. View abstract
  33. Yield of fungal surveillance cultures in pediatric hematopoietic stem cell transplant patients: a retrospective analysis and survey of current practice. Clin Infect Dis. 2014 Feb; 58(3):365-71. View abstract
  34. Short communication: The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy. AIDS Res Hum Retroviruses. 2013 Sep; 29(9):1211-7. View abstract
  35. Attitudes toward transitioning in youth with perinatally acquired HIV and their family caregivers. J Assoc Nurses AIDS Care. 2014 Mar-Apr; 25(2):168-75. View abstract
  36. Vancomycin Use for Pediatric Clostridium difficile Infection Is Increasing and Associated with Specific Patient Characteristics. Antimicrob Agents Chemother. 2013 Sep; 57(9):4307-4313. View abstract
  37. Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. J Pediatric Infect Dis Soc. 2013 Sep; 2(3):270-3. View abstract
  38. Effect of titrated parenteral nutrition on body composition after allogeneic hematopoietic stem cell transplantation in children: a double-blind, randomized, multicenter trial. Am J Clin Nutr. 2012 Feb; 95(2):342-51. View abstract
  39. CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children. PLoS One. 2008; 3(12):e3986. View abstract
  40. Changes in macronutrient intake among HIV-infected children between 1995 and 2004. Am J Clin Nutr. 2008 Aug; 88(2):384-91. View abstract
  41. Cardiometabolic disease in human immunodeficiency virus-infected children. J Cardiometab Syndr. 2008; 3(2):98-105. View abstract
  42. Accelerated cardiovascular disease and myocardial infarction risk in patients with the human immunodeficiency virus. J Cardiometab Syndr. 2008; 3(2):93-7. View abstract